KIN59

KIN59 is a purine riboside derivative that allosterically inhibits thymidine phosphorylase (TPase, IC50s = 44 and 67 µM for purified E. coli and human enzymes, respectively). Through this action, KIN59 blocks the conversion of thymidine to thymine. KIN59 inhibits TPase-induced angiogenesis in a chicken chorioallantoic membrane assay and reduces endothelial cell migration without impacting proliferation. KIN59 also inhibits the binding of fibroblast growth factor 2 (FGF2) to FGF receptor 1, preventing the growth and neovascularization of subcutaneous tumors induced by FGF2-transformed endothelial cells injected in immunodeficient nude mice.Formal Name: 5'-O-(triphenylmethyl)-inosine. CAS Number: 4152-77-6. Synonyms: 5'-O-Tritylinosine. Molecular Formula: C29H26N4O5. Formula Weight: 510.5. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 5 mg/mL, DMSO: 16 mg/mL, DMSO:PBS(pH 7.2) (1:4): 0.2 mg/mL, Ethanol: 0.3 mg/mL. SMILES: O[C@H]1[C@@H](O)[C@H](N2C=NC3=C2N=CNC3=O)O[C@@H]1COC(C4=CC=CC=C4)(C5=CC=CC=C5)C6=CC=CC=C6. InChi Code: InChI=1S/C29H26N4O5/c34-24-22(38-28(25(24)35)33-18-32-23-26(33)30-17-31-27(23)36)16-37-29(19-10-4-1-5-11-19,20-12-6-2-7-13-20)21-14-8-3-9-15-21/h1-15,17-18,22,24-25,28,34-35H,16H2,(H,30,31,36)/t22-,24-,25-,28-/m1/s1. InChi Key: YEPZMZDCXFRHCL-ZYWWQZICSA-N.