Ketogestin

Description: Ketogestin (11-Ketoprogesterone,11KP4) is a progestational steroid used in the synthesis of hormone-related drugs.Ketogestin acts through membrane glucocorticoid receptors and is an inhibitor of enzyme 11beta-hydroxysteroid dehydrogenase. It acts through membrane glucocorticoid receptors, is an inhibitor of enzyme 11beta-hydroxysteroid dehydrogenase, and also acts as a weak negative modulator of GABAA receptors. Target: Dehydrogenase, GABA Receptor. Smiles: C[C@@]12[C@@]3([C@]([C@]4([C@](C)(CC3=O)[C@@H](C(C)=O)CC4)[H])(CCC1=CC(=O)CC2)[H])[H]. References: van Rooyen D, et al., CYP17A1 exhibits 17alphahydroxylase/17,20-lyase activity towards 11beta-hydroxyprogesterone and 11-ketoprogesterone metabolites in the C11-oxy backdoor pathway. J Steroid Biochem Mol Biol. 2020 May,199:105614.