KAT8 Inhibitor 19

KAT8 inhibitor 19 is an inhibitor of lysine acetyltransferase 8 (KAT8, IC50 = 12.1 µM). It is selective for KAT8 over KAT2A, KAT2B, KAT3B, KAT6A, and KAT7 at 200 µM. KAT8 (50 µM) reduces histone 4 lysine 16 acetylation (H4K16Ac) in HT-29 colorectal carcinoma cells. It reduces the viability of HCT116, H1299, A549, and U937 cancer cells (IC50s = 39.4, 52.1, 41, and 30.1 µM, respectively).Formal Name: 4-[4,5-dihydro-3-methyl-5-oxo-4-(1H-pyrrol-2-ylmethylene)-1H-pyrazol-1-yl]-benzoic acid. CAS Number: 28532-21-0. Synonyms: Lysine Acetyltransferase 8 Inhibitor 19. Molecular Formula: C16H13N3O3. Formula Weight: 295.3. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: Acetonitrile: Soluble, DMSO: Soluble. SMILES: CC(C1=CC2=CC=CN2)=NN(C3=CC=C(C(O)=O)C=C3)C1=O. InChi Code: InChI=1S/C16H13N3O3/c1-10-14(9-12-3-2-8-17-12)15(20)19(18-10)13-6-4-11(5-7-13)16(21)22/h2-9,17H,1H3,(H,21,22). InChi Key: WBHVGUYXAZIVHV-UHFFFAOYSA-N.