JNJ-26483327
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You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
JNJ-26483327 is an inhibitor of Met. It also inhibits EGFR, HER2, and HER4 (IC50s = 9.6, 18, and... more
Product information "JNJ-26483327"
JNJ-26483327 is an inhibitor of Met. It also inhibits EGFR, HER2, and HER4 (IC50s = 9.6, 18, and 40.3 nM, respectively). JNJ-26483327 (5 or 10 µM), in combination with trastuzumab, reduces HER2 phosphorylation in BT474 breast cancer cells. It decreases tumor volume when used in combination with trastuzumab in a BT474 mouse xenograft model when administered at a dose of 75 mg/kg twice per day. InChI: InChI=1S/C22H25BrN4O2/c1-27-8-4-3-5-9-29-21-11-17-19(12-20(21)28-2)24-14-25-22(17)26-18-10-16(23)7-6-15(18)13-27/h6-7,10-12,14H,3-5,8-9,13H2,1-2H3,(H,24,25,26) InChIKey: JXDYOSVKVSQGJM-UHFFFAOYSA-N SMILES: BrC1=CC=C2C(NC3=C4C=C(OCCCCCN(C2)C)C(OC)=CC4=NC=N3)=C1
| Keywords: | 17-bromo-1,8,9,10,11,12,13,14-octahydro-20-methoxy-13-methyl-4,6-ethenopyrimido[4,5-b][6,1,12]benzoxadiazacyclopentadecine |
| Supplier: | Cayman Chemical |
| Supplier-Nr: | 44468 |
Properties
| Application: | Met inhibitor |
| MW: | 457.37 D |
| Formula: | C22H25BrN4O2 |
| Purity: | >98% |
| Format: | Solid |
Database Information
| CAS : | 807640-87-5| Matching products |
| KEGG ID : | K05099 | Matching products |
Handling & Safety
| Storage: | -20°C |
| Shipping: | +20°C (International: -20°C) |
| Signal Word: | Warning |
| GHS Hazard Pictograms: |
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| H Phrases: | H315, H319, H335 |
| P Phrases: | P261, P264, P271, P280, P302+352, P304+340, P305+351+338, P312, P321, P332+313, P337+313, P362+364, P403+233, P405, P501 |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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