JFD00244

Human sirtuin 2 (SIRT2) is a NAD+-dependent protein deacetylase with diverse targets, including alpha-tubulin, phosphoenolpyruvate carboxykinase, and forkhead box protein O1. JFD00244 is an inhibitor of SIRT2 (IC50= 56.7 µM). At 5 µM, JFD00244 induces granulocytic differentiation in the acute promyelocytic leukemia cell line NB4.Formal Name: 1,4-bis[[2-(4-hydroxyphenyl)ethyl]amino]-9,10-anthracenedione. CAS Number: 96969-83-4. Synonyms: BML-266. Molecular Formula: C30H26N2O4. Formula Weight: 478.5. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, DMSO:PBS (pH 7.2) (1:3): 0.25 mg/ml, Ethanol: 0.3 mg/ml. lambdamax: 226, 258, 596, 642 nm. SMILES: O=C(C1=C2C(NCCC3=CC=C(O)C=C3)=CC=C1NCCC4=CC=C(O)C=C4)C5=C(C=CC=C5)C2=O. InChi Code: InChI=1S/C30H26N2O4/c33-21-9-5-19(6-10-21)15-17-31-25-13-14-26(32-18-16-20-7-11-22(34)12-8-20)28-27(25)29(35)23-3-1-2-4-24(23)30(28)36/h1-14,31-34H,15-18H2. InChi Key: UUJHFIBEJJLZBF-UHFFFAOYSA-N.