Jatrorrhizine (chloride)

Jatrorrhizine is an alkaloid that has been found in the Chinese herb C. chinensis and has diverse biological activities. It is active against P. falciparum (IC50s = 422 and 1,607 ng/ml for D-6 and W-2 clones, respectively) and E. histolytica (IC50 = 82.7 µM). Jatrorrhizine inhibits the growth of C8161 human melanoma cells in vitro (IC50 = 47.4 µM) and inhibits C8161 cell-mediated neovascularization in a Matrigel(TM) plug assay in mice when administered at a dose of 50 µg/animal. It reduces serum levels of triglycerides, LDL cholesterol (LDL-C), aspartate transaminase (AST), and alanine aminotransferase (ALT) in a high-fat diet-induced mouse model of hyperlipidemia when administered at doses of 20 and 100 mg/kg. Jatrorrhizine is also a metabolite of berberine (Cay-10006427).Formal Name: 5,6-dihydro-3-hydroxy-2,9,10-trimethoxy-dibenzo[a,g]quinolizinium, monochloride. CAS Number: 6681-15-8. Synonyms: NSC 645313. Molecular Formula: C20H20NO4 . Cl. Formula Weight: 373.8. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 0.1 mg/ml. lambdamax: 227, 266, 351, 437 nm. SMILES: COC1=CC=C2C(C=[N+](CCC3=C4C=C(OC)C(O)=C3)C4=C2)=C1OC.[Cl-]. InChi Code: InChI=1S/C20H19NO4.ClH/c1-23-18-5-4-12-8-16-14-10-19(24-2)17(22)9-13(14)6-7-21(16)11-15(12)20(18)25-3,/h4-5,8-11H,6-7H2,1-3H3,1H. InChi Key: JKMUUZMCSNHBAX-UHFFFAOYSA-N. Origin: Plant/Mahoniae Caulis.