IWP-12

IWP-12 is a small molecule inhibitor of porcupine (PORCN), which is an acyltransferase that palmitoylates and activates Wnt proteins. IWP-12 inhibits cell-autonomous Wnt signaling with an IC50 value of 15 nM.Formal Name: N-(6-methyl-2-benzothiazolyl)-2-[(3,4,6,7-tetrahydro-3,6-dimethyl-4-oxothieno[3,2-d]pyrimidin-2-yl)thio]-acetamide. CAS Number: 688353-45-9. Synonyms: Inhibitor of Wnt Production-12. Molecular Formula: C18H18N4O2S3. Formula Weight: 418.6. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 5 mg/ml, DMF:PBS(pH7.2) (1:2): 0.3 mg/ml, DMSO: 2 mg/ml. lambdamax: 278, 302, 335 nm. SMILES: O=C(CSC(N1C)=NC2=C(SC(C)C2)C1=O)NC3=NC4=C(C=C(C)C=C4)S3. InChi Code: InChI=1S/C18H18N4O2S3/c1-9-4-5-11-13(6-9)27-17(19-11)21-14(23)8-25-18-20-12-7-10(2)26-15(12)16(24)22(18)3/h4-6,10H,7-8H2,1-3H3,(H,19,21,23). InChi Key: RBFDSBJDWZOTGR-UHFFFAOYSA-N.