This website uses cookies, which are necessary for the technical operation of the website and are always set. Other cookies, which increase the comfort when using this website, are used for direct advertising or to facilitate interaction with other websites and social networks, are only set with your consent.
Configuration
Technically required
These cookies are necessary for the basic functions of the shop.
"Allow all cookies" cookie
"Decline all cookies" cookie
CSRF token
Cookie preferences
Currency change
Customer-specific caching
FACT-Finder tracking
Individual prices
Selected shop
Session
Comfort functions
These cookies are used to make the shopping experience even more appealing, for example for the recognition of the visitor.
Note
Show the facebook fanpage in the right blod sidebar
Statistics & Tracking
Affiliate program
Conversion and usertracking via Google Tag Manager
Isotretinoin is a retinoid that is converted in vivo into all-trans retinoic acid (Cay-11017) and has diverse biological activities. It increases the doubling time and transcription of retinoic acid receptor beta (RARbeta) mRNA in Hep2, FaDu, CCL-17, SCC-9, SCC-15, and SCC-25 human oral squamous cell carcinoma cells when used at a concentration of 1 µM. Isotretinoin inhibits proliferation of primary human sebocytes (IC50 = 10 µM). It also decreases triglyceride, stearyl ester, and free fatty acid synthesis and modulates keratin expression in primary human sebocytes at a concentration of 0.1 µM. Isotretinoin (2 mg/kg per day) reduces chronic rejection damage and decreases mRNA expression of IFN-gamma and IL-10 in allografts in chronic Fisher344?Lewis transplant mice, an allograft nephropathy model. It also slows rod and cone recovery and prevents light-induced photoreceptor damage in an albino rat model of photoreceptor degeneration when administered at a dose of 40 mg/kg. Formulations containing isotretinoin have been used in the treatment of severe recalcitrant nodular acne.Formal Name: 13-cis-retinoic acid. CAS Number: 4759-48-2. Synonyms: AGN 190013, 13(Z)-Retinoic Acid, 13-cis-Vitamin A Acid. Molecular Formula: C20H28O2. Formula Weight: 300.4. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 5 mg/ml, DMF:PBS (pH 7.2) (1:4): 0.2 mg/ml, DMSO: 1 mg/ml. lambdamax: 242, 356 nm. SMILES: CC1=C(/C=C/C(C)=C/C=C/C(C)=C\C(O)=O)C(C)(C)CCC1. InChi Code: InChI=1S/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/b9-6+,12-11+,15-8+,16-14-. InChi Key: SHGAZHPCJJPHSC-XFYACQKRSA-N.
Keywords:
13(Z)-Retinoic Acid, 13-cis-Vitamin A Acid, AGN 190013, 13-cis-retinoic acid
This website uses cookies, which are necessary for the technical operation of the website and are always set. Other cookies, which increase the usability of this website, serve for direct advertising or simplify interaction with other websites and social networks, will only be used with your consent.
More information