IQ-1S (free acid)

IQ-1S (free acid) is an inhibitor of NF-kappaB/AP-1 (IC50 = 2.3 µM in a reporter assay). It inhibits TNF-alpha and IL-6 production in human Mono-Mac-6 cells (IC50s = 1.3 and 3.8 µM, respectively) and isolated human peripheral blood mononuclear cells (PBMCs, IC50s = 2.6 and 5.6 µM, respectively), as well as nitric oxide (NO) production in murine J774-A.1 macrophages (IC50 = 3.1 µM). IQ-1S (free acid) binds to JNKs (Kd = 0.24, 0.36, and 0.1µM for JNK1-3), as well as casein kinase 1delta (CK1delta), PI3Kgamma, and MAPK-interacting serine/threonine kinase 2 (MKNK2, Kds = 0.38, 0.47, and 0.92 µM, respectively).Formal Name: 11H-indeno[1,2-b]quinoxalin-11-one, oxime. CAS Number: 23146-22-7. Synonyms: IQ-1. Molecular Formula: C15H9N3O. Formula Weight: 247.3. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMF: 15mg/mL, DMF:PBS (pH 7.2) (1:2): 0.3mg/mL, DMSO: 10mg/mL. SMILES: O/N=C1C2=C(C=CC=C2)C3=NC4=CC=CC=C4N=C3\1. InChi Code: InChI=1S/C15H9N3O/c19-18-14-10-6-2-1-5-9(10)13-15(14)17-12-8-4-3-7-11(12)16-13/h1-8,19H/b18-14+. InChi Key: SZHHSFHOIDCNLD-NBVRZTHBSA-N.