Insulin Sensitizer C59

A potentiator of insulin-induced Glut4 plasma membrane translocation, enhances insulin-stimulated increases in plasma membrane levels of Glut4 in a reporter assay using C2C12 cells at 10 µM, decreases fasting blood levels of glucose, fasting plasma levels of insulin, and body weight in mice fed a high-fat diet at 10 mg/kg per day, potentiates insulin-induced increases in the plasma membrane translocation of Glut4 in the forelimbs, hind limbs, brown adipose tissues, and heart but not brain or liver in mice in a model of diet-induced obesity. Formulation: A solid. InChI: InChI=1S/C16H18Cl2N2O/c17-12-4-14(19-8-13(12)18)20-15(21)16-5-9-1-10(6-16)3-11(2-9)7-16/h4,8-11H,1-3,5-7H2,(H,19,20,21)/t9-,10+,11-,16?. InChIKey: RBBBMHRIAFVEFR-NROJINRZSA-N. SMILES: O=C(C1(C[C@@H](C2)C3)C[C@@H]3C[C@@H]2C1)NC(N=C4)=CC(Cl)=C4Cl