Inflachromene

Item number	Size	Datasheet	Manual	SDS	Delivery time	Price
TGM-T24167-1mg	1 mg	-	-	-	7 - 10 business days*	110.00€
TGM-T24167-5mg	5 mg				7 - 10 business days*	273.00€
TGM-T24167-1mL	1 ml				7 - 10 business days*	300.00€
TGM-T24167-10mg	10 mg				7 - 10 business days*	437.00€
TGM-T24167-25mg	25 mg				7 - 10 business days*	747.00€
TGM-T24167-50mg	50 mg				7 - 10 business days*	1,023.00€
TGM-T24167-100mg	100 mg				7 - 10 business days*	1,383.00€

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Description: Inflachromene (ICM) is an inhibitor of HMGB1 and HMGB expression with... more

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Product information "Inflachromene"

Description: Inflachromene (ICM) is an inhibitor of HMGB1 and HMGB expression with anti-inflammatory activity.Inflachromene reduces seizure severity in a mouse model of epilepsy by inhibiting HMGB1 translocation, inhibits endothelial proliferation through the HMGB1/2-regulated TLR4-NF-kappaB pathway, and inhibits autophagy by regulating Beclin 1 activity. Inflachromene can be used to study epilepsy. Target: Others. Smiles: CC1(C)Oc2cc(O)ccc2C2C1=CCn1n2c(=O)n(-c2ccccc2)c1=O. References: Lee S, et, al. A small molecule binding HMGB1 and HMGB2 inhibits microglia-mediated neuroinflammation. Nat Chem Biol. 2014 Dec, 10(12): 1055-60.

Keywords:	ICM
Supplier:	TargetMol
Supplier-Nr:	T24167

Properties

MW:	377.39 D
Formula:	C21H19N3O4

Database Information

Handling & Safety

Storage:	+4°C
Shipping:	+20°C (International: +4°C)

Caution
Our products are for laboratory research use only: Not for administration to humans!

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