Indole-3-carboxylic Acid

Indole-3-carboxylic acid is a plant metabolite derived from tryptophan that has been found in Arabidopsis and has diverse biological activities. It induces resistance in Arabidopsis against the plant necrotrophic fungus P. cucumerina when applied as a soil-drenching solution at a concentration of 150 µM prior to infection. Indole-3-carboxylic acid is cytotoxic to A549 human lung and MCF-7 human breast cancer cells (EC50s = 4.6 and 12.9 µg/ml, respectively) and inhibits HIV replication in infected H9 lymphocytes (IC50 = 16.4 µg/ml). Indole-3-carboxylic acid has also been used as a precursor in the synthesis of substituted thiadiazoles with anticancer activity.Formal Name: 1H-indole-3-carboxylic acid. CAS Number: 771-50-6. Synonyms: I3CA, ICOOH, Indole-beta-carboxylic Acid, beta-Indolylcarboxylic Acid. Molecular Formula: C9H7NO2. Formula Weight: 161.2. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, DMSO:PBS (pH 7.2) (1:8): 0.11 mg/ml, Ethanol: 1 mg/ml. lambdamax: 213, 281 nm. SMILES: O=C(O)C1=CNC2=CC=CC=C21. InChi Code: InChI=1S/C9H7NO2/c11-9(12)7-5-10-8-4-2-1-3-6(7)8/h1-5,10H,(H,11,12). InChi Key: KMAKOBLIOCQGJP-UHFFFAOYSA-N. Origin: Synthetic.