Indium (III) thiosemicarbazone 5b

Indium (III) thiosemicarbazone 5b is an anticancer agent. It is cytotoxic to A549, MCF-7 breast, MCF-7/DDP cisplatin-resistant breast, and Hl 7702 liver cancer cells (IC50s = 2.41, 1.97, 2.11, and 8.95 µM, respectively). Indium (III) thiosemicarbazone 5b decreases PI3K, Akt, mTOR, P-gp, and GSH levels in MCF-7/DDP cells. In vivo, indium (III) thiosemicarbazone 5b (2.5 µmol/kg) reduces tumor weight and volume in an MCF-7/DDP mouse xenograft model. Liposomes containing indium (III) thiosemicarbazone 5b also induce apoptosis and pro-death autophagy in MCF-7/DDP cells, as well as reduce tumor volume and weight in an MCF-7/DDP mouse xenograft model.Formal Name: (OC-6-43)-dichloro[N,N-dimethyl-2-[(2-pyridinyl-kappaN)methylene]hydrazinecarbothioamide-kappaN2,kappaS]methoxy-indium. CAS Number: 2345755-20-4. Molecular Formula: C10H15Cl2InN4OS. Formula Weight: 425.0. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: DMF: 10 mg/mL, DMF:PBS (pH 7.2) (1:2): 0.30 mg/mL, DMSO: 1 mg/mL, Ethanol: Slightly Soluble. lambdamax: 302, 411 nm. SMILES: [Cl-][In+3]12([O-]C)([S]=C([N](C)C)[NH][N]1=CC3=CC=CC=[N]32)[Cl-]. InChi Code: InChI=1S/C9H12N4S.CH3O.2ClH.In/c1-13(2)9(14)12-11-7-8-5-3-4-6-10-8,1-2,,,/h3-7H,1-2H3,(H,12,14),1H3,2*1H,/q,-1,,,+3/p-2/b11-7+,,,,. InChi Key: VNKHZVLDFDLQKI-UTUIWUMXSA-L.