Imidafenacin

Imidafenacin is an antagonist of muscarinic acetylcholine receptors (mAChRs, Kis = 7.55, 22.6, 1.42, 8.86, and 2.63 nM, respectively, for recombinant human M1-M5 receptors). It binds to isolated guinea pig bladders (Kb = 0.813 nM) and inhibits ACh release from isolated rat bladders (IC50 = 0.747 nM). Imidafenacin (10-300 µg/kg) reduces urine volume in orally water-loaded rats. Formulations containing imidafenacin have been used in the treatment of overactive bladder.Formal Name: 2-methyl-alpha,alpha-diphenyl-1H-imidazole-1-butanamide. CAS Number: 170105-16-5. Synonyms: KRP 197, ONO-8025. Molecular Formula: C20H21N3O. Formula Weight: 319.4. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMF: Slightly soluble, DMSO: Slightly soluble. SMILES: O=C(C(C1=CC=CC=C1)(CCN2C(C)=NC=C2)C3=CC=CC=C3)N. InChi Code: InChI=1S/C20H21N3O/c1-16-22-13-15-23(16)14-12-20(19(21)24,17-8-4-2-5-9-17)18-10-6-3-7-11-18/h2-11,13,15H,12,14H2,1H3,(H2,21,24). InChi Key: SQKXYSGRELMAAU-UHFFFAOYSA-N.