IM-156 (acetate)

IM-156 is an inhibitor of mitochondrial complex I, also known as NADH dehydrogenase (IC50 = 2.2 µM) and an activator of AMP-activated protein kinase alpha (AMPKalpha). It reduces the oxygen consumption rate (OCR, IC50 = 3.3 µM) and decreases mitochondrial ATP production in Eµ-Myc mouse lymphoma cells. IM-156 (10, 30, and 50 µM) increases AMPKalpha activity in primary rat peritoneal mesothelial cells and protects against chlorhexidine-induced peritoneal fibrosis in rats when administered at a dose of 1 mg/kg. It reduces tumor growth in an AT-84 murine oral cancer model and decreases age-related decline in novel object recognition, spatial working, and contextual memory in mice.Formal Name: N-[imino[[4-(trifluoromethoxy)phenyl]amino]methyl]-1-pyrrolidinecarboximidamide, acetate. CAS Number: 2043654-54-0. Synonyms: HL156A, HL271. Molecular Formula: C13H16F3N5O . XC2H4O2. Formula Weight: 315.3. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMF: 1 mg/ml, DMSO: 1 mg/ml, Ethanol: 1 mg/ml. lambdamax: 253 nm. SMILES: FC(F)(OC1=CC=C(NC(NC(N2CCCC2)=N)=N)C=C1)F.CC(O)=O. InChi Code: InChI=1S/C13H16F3N5O.C2H4O2/c14-13(15,16)22-10-5-3-9(4-6-10)19-11(17)20-12(18)21-7-1-2-8-21,1-2(3)4/h3-6H,1-2,7-8H2,(H4,17,18,19,20),1H3,(H,3,4). InChi Key: AGFDCTOLSXWRDZ-UHFFFAOYSA-N.