IL-4-inhibitor-1

Item number	Size	Delivery time	Price
TGM-T36527-1mg	1 mg	7 - 10 business days*	40.00€
TGM-T36527-1mL	1 ml	7 - 10 business days*	161.00€
TGM-T36527-5mg	5 mg	7 - 10 business days*	184.00€
TGM-T36527-10mg	10 mg	7 - 10 business days*	345.00€
TGM-T36527-25mg	25 mg	7 - 10 business days*	587.00€
TGM-T36527-50mg	50 mg	7 - 10 business days*	840.00€
TGM-T36527-100mg	100 mg	7 - 10 business days*	1,160.00€

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Description: IL-4 inhibitor is an inhibitor of IL-4.1It binds to IL-4 with a Kdvalue of 1.8 µM... more

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Product information "IL-4-inhibitor-1"

Description: IL-4 inhibitor is an inhibitor of IL-4.1It binds to IL-4 with a Kdvalue of 1.8 µM and inhibits IL-4 activity in a cell-based reporter assay (EC50= 1.81 µM). It is selective for IL-4 over IL-13 (EC50= 18.2 µM). IL-4 inhibitor inhibits IL-4-induced STAT6 phosphorylation in THP-1 monocytes (EC50= 3.1 µM), indicating inhibition of the IL-4-JAK1-STAT6 signaling pathway. Target: IL Receptor. Smiles: Nc1nc(cc(-c2ccc(O)c(O)c2)c1C#N)-c1ccc(F)cc1. References: Quinnell, S.P., Leifer, B.S., Nestor, S.T., et al.A small-molecule inhibitor to the cytokine interleukin-4ACS Chem. Biol.15(10)2649-2654(2020)

Supplier:	TargetMol
Supplier-Nr:	T36527

Properties

Application:	IL-4 inhibitor
MW:	321.31 D
Formula:	C18H12FN3O2

Database Information

CAS :	1332184-63-0\| Matching products
KEGG ID :	K05430 \| Matching products

Handling & Safety

Storage:	-20°C
Shipping:	+4°C (International: +4°C)

Caution
Our products are for laboratory research use only: Not for administration to humans!

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