Ici 216140

Description: ICI 216140 is a GRP/bombesin receptor 2 antagonist (IC50: 2 nM in vitro). At 2 mg/kg, it can decrease bombesin-stimulated pancreatic amylase secretion in rats. At 1 mM, it has been proved to attenuate bombesin-stimulated increases in blood pressure in rats. Target: Others. Smiles: C([C@H](NC([C@H](CC1=CN=CN1)NC(C(C)C)=O)=O)C(N[C@H](C(N[C@H](C(N[C@@H](C(N[C@@H](CC2=CN=CN2)C(N[C@H](C(NC)=O)CC(C)C)=O)=O)C)=O)[C@H](C)C)=O)C)=O)C=3C=4C(NC3)=CC=CC4. References: Ryan RR, Taylor JE, Daniel JL, Cowan A. Pharmacological profiles of two bombesin analogues in cells transfected with human neuromedin B receptors. Eur J Pharmacol. 1996 Jun 13,306(1-3):307-14. PubMed PMID: 8813645.