IBTP (iodide)

IBTP is a lipophilic cation that is accumulated in mitochondria and forms stable thioether adducts in a thiol-specific manner. As a result, mitochondrial proteins that have changed thiol redox state following oxidative stress are selectively tagged with IBTP and can be separated by two-dimensional electrophoresis and isolated. IBTP-tagged proteins can also be evaluated by immunoblotting using an antibody directed against the triphenylphosphonium moiety of the IBTP molecule. IBTP has also been used as a mitochondria-targeted soft electrophile to inhibit mitochondrial oxidative phosphorylation.Formal Name: (4-iodobutyl)triphenyl-phosphonium, monoiodide. CAS Number: 159085-21-9. Molecular Formula: C22H23IP . I. Formula Weight: 572.2. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMSO: 100mM, Ethanol: 50mM. SMILES: ICCCC[P+](C1=CC=CC=C1)(C2=CC=CC=C2)C3=CC=CC=C3.[I-]. InChi Code: InChI=1S/C22H23IP.HI/c23-18-10-11-19-24(20-12-4-1-5-13-20,21-14-6-2-7-15-21)22-16-8-3-9-17-22,/h1-9,12-17H,10-11,18-19H2,1H/q+1,/p-1. InChi Key: XWDMWKLGLADJFM-UHFFFAOYSA-M.