Hypaconitine

Hypaconitine is a diterpene alkaloid that has been found in Aconitum and has diverse biological activities. It inhibits nerve stimulation-evoked contractions in isolated mouse phrenic nerve-diaphragm muscle preparations (IC50 = 118 nM). Hypaconitine (0.025 mg/kg) prevents carrageenan-induced paw edema and reduces acetic acid-induced writhing in mice (ED50 = 0.1 mg/kg). Hypaconitine is toxic to mice (LD50 = 1.9 mg/kg, s.c.).Formal Name: (1alpha,6alpha,14alpha,15alpha,16beta)-1,6,16-trimethoxy-4-(methoxymethyl)-20-methyl-aconitane-8,13,14,15-tetrol, 8-acetate 14-benzoate. CAS Number: 6900-87-4. Molecular Formula: C33H45NO10. Formula Weight: 615.7. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: DMF: 15mg/mL, DMF:PBS (pH 7.2) (1:4): 0.2mg/mL, DMSO: 10mg/mL, Ethanol: 5mg/mL. lambdamax: 231 nm. SMILES: CO[C@@H]1C2(C3N4C)[C@@]([C@@H](OC)C3[C@]([C@@H](O)[C@H](OC)[C@]5(O)[C@@H]6OC(C7=CC=CC=C7)=O)(OC(C)=O)[C@]6([H])[C@]2(C5)[H])([H])[C@](COC)(C4)CC1. InChi Code: InChI=1S/C33H45NO10/c1-17(35)44-33-21-19(14-31(38,28(42-6)26(33)36)27(21)43-29(37)18-10-8-7-9-11-18)32-20(40-4)12-13-30(16-39-3)15-34(2)25(32)22(33)23(41-5)24(30)32/h7-11,19-28,36,38H,12-16H2,1-6H3/t19-,20+,21-,22?,23+,24-,25?,26+,27-,28+,30+,31-,32?,33-/m1/s1. InChi Key: FIDOCHXHMJHKRW-WNDRHIBVSA-N. Origin: Plant/Aconitum carmichaelii Debx.