Hydroxycitric acid

Description: (-)-Hydroxycitric acid (HCA) can inhibit fat synthesis and reduces food intake, the primary mechanism of action of HCA appears to be related to its ability to act as a competitive inhibitor of the enzyme ATP-citrate lyase, which catalyzes the conversion of citrate and coenzyme A to oxaloacetate and acetyl coenzyme A (acetyl-CoA), primary building blocks of fatty acid and cholesterol synthesis. Target: p38 MAPK, ERK, Fatty Acid Synthase. Smiles: C(C(C(O)=O)O)(CC(O)=O)(C(O)=O)O. References: Safety assessment of (-)-hydroxycitric acid and Super CitriMax, a novel calcium/potassium salt.Food Chem Toxicol. 2004 Sep,42(9):1513-29.