HTMT (maleate)

HTMT is a histamine H1 receptor agonist. It also binds to the histamine H4 receptor (Ki = 1.2 µM) but does not increase calcium mobilization in HEK293 cells expressing the receptor at 10 µM. HTMT increases intracellular calcium and inositol phosphate levels (EC50s = 19 and 30 µM, respectively) in human peripheral blood lymphocytes. It increases proliferation of immortalized mouse small, but not large, cholangiocytes, when used at a concentration of 10 µM. HTMT (10 µg/kg twice per day) increases levels of sheep red blood cell-induced IgG and IgM antibodies in rabbit serum. It induces scratching in mice when administered at an intradermal dose of 0.2 µmol, an effect that is reduced by the H1 receptor antagonist terfenadine (Cay-20305).Formal Name: 6-[[2-(1H-imidazol-5-yl)ethyl]amino]-N-[4-(trifluoromethyl)phenyl]-heptanamide, 2Z-butenedioate. CAS Number: 195867-54-0. Synonyms: Histamine trifluromethyl toluidine. Molecular Formula: C19H25F3N4O . 2C4H4O4. Formula Weight: 614.6. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMF: 30 mg/ml, DMSO: 25 mg/ml, Ethanol: 10 mg/ml, PBS (pH 7.2): 10 mg/ml. lambdamax: 250 nm. SMILES: FC(F)(F)C1=CC=C(NC(CCCCC(C)NCCC2=CN=CN2)=O)C=C1.O=C(O)/C=C\C(O)=O.O=C(O)/C=C\C(O)=O. InChi Code: InChI=1S/C19H25F3N4O.2C4H4O4/c1-14(24-11-10-17-12-23-13-25-17)4-2-3-5-18(27)26-16-8-6-15(7-9-16)19(20,21)22,2*5-3(6)1-2-4(7)8/h6-9,12-14,24H,2-5,10-11H2,1H3,(H,23,25)(H,26,27),2*1-2H,(H,5,6)(H,7,8)/b,2*2-1-. InChi Key: ODAOZWTYNWZSBY-SPIKMXEPSA-N.