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You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
The biology of highly reactive oxygen radical species is of great interest in many biomedical... more
Product information "HPF"
The biology of highly reactive oxygen radical species is of great interest in many biomedical research disciplines, including neurodegeneration, aging, cancer, and infectious diseases. There are a number of fluorescent reagents, such as 2,7-dichlorodihydrofluorescein (DCDHF), that can be used to detect free radicals, but they have significant limitations due to their facile oxidation by light and numerous non-radical oxidants such as hydrogen peroxide (H2O2). HPF is a cell-permeable aromatic amino-fluorescein derivative that has little intrinsic fluorescence. It undergoes oxidation only by highly reactive oxygen species (hROS) such as the hydroxyl radical, peroxynitrite, and hROS generated from a peroxidase/H2O2 system. It is inert to hypochlorite ion, nitric oxide, hydrogen peroxide (H2O2), superoxide, and other oxidants. Upon oxidation, HPF is converted to the highly fluorescent molecule fluorescein, with excitation/emission maxima of 490/515 nm, respectively, allowing the simple direct detection of highly reactive biological radicals.Formal Name: (2-[6-(4'-hydroxy)phenoxy-3H-xanthene-3-on-9-yl]benzoic acid. CAS Number: 359010-69-8. Molecular Formula: C26H16O6. Formula Weight: 424.4. Purity: >98%. Formulation: (Request formulation change), A solution in methyl acetate. Solubility: DMF: 20 mg/ml, DMSO: 20 mg/ml, Ethanol: 20 mg/ml, Ethanol:PBS (pH 7.2)(1:8): .15 mg/ml. lambdamax: 228, 277 nm. SMILES: OC(C=C1)=CC=C1OC2=CC3=C(C=C2)C4(C(C=CC=C5)=C5C(O4)=O)C6=CC=C(O)C=C6O3. InChi Code: InChI=1S/C26H16O6/c27-15-5-8-17(9-6-15)30-18-10-12-22-24(14-18)31-23-13-16(28)7-11-21(23)26(22)20-4-2-1-3-19(20)25(29)32-26/h1-14,27-28H. InChi Key: NPOSMYDPUKBGQL-UHFFFAOYSA-N.
Keywords: | (2-[6-(4'-hydroxy)phenoxy-3H-xanthene-3-on-9-yl]benzoic acid |
Supplier: | Cayman Chemical |
Supplier-Nr: | 10159 |
Properties
Application: | Detection of radicals |
MW: | 424.4 D |
Formula: | C26H16O6 |
Purity: | >98% |
Format: | Solution |
Database Information
CAS : | 359010-69-8| Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | +20°C (International: -20°C) |
Signal Word: | Danger |
GHS Hazard Pictograms: |
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H Phrases: | H225, H319, H336, H303 |
P Phrases: | P210, P240, P241, P242, P243, P261, P264, P271, P280, P312, P303+P361+P353, P304+P340, P305+P351+P338, P337+P313, P370+P378, P405, P403+P233, P403+P235, P501 |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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