HOR1-C59

An Or5V1 agonist, induces Galphas-Gbetagamma dissociation in HEK293 cells overexpressing human Or5V1 (EC50 = 7.12 nM), improves glucose tolerance, increases gluconeogenesis, and decreases liver steatosis and epididymal adipocyte size in high-fat diet-fed mice at 50 ng/g. SMILES: O=C([C@H]1[C@@H](OC(C)(O1)C)C(NCC2=CC=CC=C2)=O)NCC3=CC=CC=C3. InChi Code: InChI=1S/C21H24N2O4/c1-21(2)26-17(19(24)22-13-15-9-5-3-6-10-15)18(27-21)20(25)23-14-16-11-7-4-8-12-16/h3-12,17-18H,13-14H2,1-2H3,(H,22,24)(H,23,25)/t17-,18-/m1/s1. InChi Key: BGPXLBACWHVXTA-QZTJIDSGSA-N