Homoplantaginin

Homoplantaginin is a flavonoid glycoside that has been found in S. plebeia and has antioxidant and anti-inflammatory activities. It scavenges 2,2-diphenyl-1-picrylhydrazyl (DPPH, Cay-14805) radicals with an IC50 value of 0.35 µg/ml in a cell-free assay. Homoplantaginin reverses hydrogen peroxide-induced decreases in glutathione (GSH) levels and glutathione peroxidase (GPX) and superoxide dismutase (SOD) activity in HL-7702 cells when used at concentrations ranging from 1 to 100 µg/ml. It reduces protein levels of toll-like receptor 4 (TLR4), MyD88, caspase-1, and IL-1beta induced by palmitic acid (Cay-10006627) in human umbilical vein endothelial cells (HUVECs) when used at concentrations of 1 and 10 µM. Homoplantaginin (50 and 100 mg/kg) decreases serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), TNF-alpha, and IL-1 levels, as well as reduces liver inflammatory cell infiltration and hepatocyte necrosis in a mouse model of immunological liver injury induced by Bacillus Calmette-Guérin (BCG) vaccine and LPS.Formal Name: 7-(beta-D-glucopyranosyloxy)-5-hydroxy-2-(4-hydroxyphenyl)-6-methoxy-4H-1-benzopyran-4-one. CAS Number: 17680-84-1. Synonyms: Hispidulin-7-O-D-glucoside. Molecular Formula: C22H22O11. Formula Weight: 462.4. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: DMF: 25mg/mL, DMSO: 20mg/mL. SMILES: OC1=C(C(C=C(C2=CC=C(O)C=C2)O3)=O)C3=CC(O[C@H]4[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O4)=C1OC. InChi Code: InChI=1S/C22H22O11/c1-30-21-14(32-22-20(29)19(28)17(26)15(8-23)33-22)7-13-16(18(21)27)11(25)6-12(31-13)9-2-4-10(24)5-3-9/h2-7,15,17,19-20,22-24,26-29H,8H2,1H3/t15-,17-,19+,20-,22-/m1/s1. InChi Key: GCLAFEGUXXHIFT-IWLDQSELSA-N. Origin: Plant/Salvia plebeia R. Br..