Homogentisic acid

Description: 1. Homogentisic acid (2,5-dihydroxyphenylacetic acid) shows interesting antioxidant and antiradical activities, and protective effect against thermal-cholesterol degradation, comparable to those of well known antioxidants. 2. Homogentisic acid is the primary precursor of melanin synthesis in Vibrio cholerae, a Hyphomonas strain, and Shewanella colwelliana. 3. A derivative of homogentisic acid which inhibits Pfnek-1 with an IC(5) around 1.8 muM, this product is moderately active in vitro against a FcB1 P. falciparum strain (IC(5) = 12 muM). Target: Endogenous Metabolite, Antioxidant. Smiles: OC(=O)Cc1cc(O)ccc1O. References: Hughes A T , Milan A M , Davison A S , et al. Serum markers in alkaptonuria: simultaneous analysis of homogentisic acid, tyrosine and nitisinone by liquid chromatography tandem mass spectrometry[J]. Annals of Clinical Biochemistry: An international journal of biochemistry and laboratory medicine, 2015:0004563215571969.