Herbacetin

Herbacetin is a natural product that acts as a selective inhibitor of ornithine decarboxylase (ODC). It inhibits recombinant and HCT116 and HT29 colon cancer cell-derived ODC in a dose-dependent manner while having no effect on 13 tested kinases or S-adenosylmethionine decarboxylase in vitro. Herbacetin suppresses anchorage-independent growth, activation of activator protein-1 (AP-1), a MAP kinase transcription factor, and phosphorylation of ERK1/2 and p90RSK in vitro. It suppresses HCT116 xenograft tumor growth in mice without significant body weight loss when administered i.p. or orally. Herbacetin also inhibits acetylcholinesterase (AChE, IC50 = 1.37 µM) in vitro.Formal Name: 3,5,7,8-tetrahydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one. CAS Number: 527-95-7. Synonyms: Isoarticulatidin, 8-hydroxy Kaempferol, 3,5,7,8,4'-Pentahydroxyflavone. Molecular Formula: C15H10O7. Formula Weight: 302.2. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/mL, DMSO: 30 mg/mL, DMSO:PBS(pH 7.2) (1:4): 1 mg/mL, Ethanol: 2 mg/mL. lambdamax: 278, 331, 386 nm. SMILES: OC1=CC(O)=C(C(C(O)=C(C2=CC=C(O)C=C2)O3)=O)C3=C1O. InChi Code: InChI=1S/C15H10O7/c16-7-3-1-6(2-4-7)14-13(21)12(20)10-8(17)5-9(18)11(19)15(10)22-14/h1-5,16-19,21H. InChi Key: ZDOTZEDNGNPOEW-UHFFFAOYSA-N.