Hematoporphyrin (hydrochloride)

Hematoporphyrin is a photosensitizer. Hematoporphyrin (3 µM) increases oxygen consumption and decreases the respiratory control ratio (RCR) in irradiated isolated rat liver mitochondria. It induces DNA breaks in cell-free assays, but not in human HeLa cervical cancer cells, in a light-dependent manner when used at a concentration of 6 µM. Hematoporphyrin (12 µM) decreases the survival of irradiated, but not non-irradiated, HeLa cells. Hematoporphyrin (5 mg/kg) decreases growth of subcutaneous Yoshida AH-130 hepatoma tumors in rats when administered with radiation.Formal Name: 7,12-bis(1-hydroxyethyl)-3,8,13,17-tetramethyl-21H,23H-porphine-2,18-dipropanoic acid, dihydrochloride. CAS Number: 17696-69-4. Synonyms: Haematoporphyrin, Hematoporphyrin IX. Molecular Formula: C34H38N4O6 . 2HCl. Formula Weight: 671.6. Purity: >90% (mixture of isomers). Formulation: (Request formulation change), A solid. Solubility: DMF: 5 mg/ml, DMSO: 5 mg/ml, Ethanol: 2 mg/ml, PBS (pH 7.2): 0.5 mg/ml. lambdamax: 392 nm. SMILES: CC1=C2[NH]C(/C=C(C(CCC(O)=O)=C3C)\[N]=C3/C=C4[NH]/C(C(C(O)C)=C\4C)=C\C5=[N]/C(C(C(C)O)=C5C)=C\2)=C1CCC(O)=O.Cl.Cl. InChi Code: InChI=1S/C34H38N4O6.2ClH/c1-15-21(7-9-31(41)42)27-14-28-22(8-10-32(43)44)16(2)24(36-28)12-29-34(20(6)40)18(4)26(38-29)13-30-33(19(5)39)17(3)25(37-30)11-23(15)35-27,,/h11-14,19-20,36-37,39-40H,7-10H2,1-6H3,(H,41,42)(H,43,44),2*1H/b23-11-,24-12-,25-11-,26-13-,27-14-,28-14-,29-12-,30-13-,,. InChi Key: QCLJGYHFHNRFIL-UDHHKLSBSA-N.