Heliquinomycin

Description: Heliquinomycin is a bacterial metabolite originally isolated fromStreptomycesthat has diverse biological activities.1It is active against a variety of Gram-positive bacteria, including strains ofB. anthracis, B. subtilis, and methicillin-sensitive or -resistantS. aureus(MICs = <0.05-0.39 µg/ml). Heliquinomycin inhibits the activity of DNA helicase with a Kivalue of 6.8 µM. It reduces the growth of L1210 leukemia, B16 melanoma, and FS-3 fibrosarcoma cells (IC50s = 0.97, 0.89, and 0.83 µg/ml, respectively). Target: Others. Smiles: CO[C@@H]1C[C@H](O[C@@H]2c3c(O[C@@]22Oc4c(C[C@H]2O)cc2cc(oc(=O)c2c4O)C(=O)OC)c(O)c2C(=O)C(OC)=CC(=O)c2c3O)O[C@@H](C)[C@@H]1O , c:42, . References: Chino, M., Nishikawa, K., Umekita, M., et al.Heliquinomycin, a new inhibitor of DNA helicase, produced by Streptomyces sp. MJ929-SF2 I. Taxonomy, production, isolation, physico-chemical properties and biological activitiesJ. Antibiot. (Tokyo)49(8)752-757(1996)