Harmine

Peroxisome proliferator-activated receptor gamma (PPARgamma) is a central regulator of adipocyte differentiation and is the principle target of the thiazolidinedione (TZD) class of antidiabetic drugs. Harmine is a beta-carboline alkaloid that was first isolated from seeds of Peganum harmala (Syrian rue) and Banisteriopsis caapi. Recent work indicates that harmine is a unique regulator of PPARgamma expression that acts by inhibiting the Wnt signalling pathway in a cell-specific manner. Administration of harmine (30 mg/kg) to obese db/db mice resulted in reduced blood glucose, free fatty acids, and triglyceride levels, delayed hyperglycemia, and improved insulin sensitivity. Harmine also attenuates inflammatory gene expression (TNF-alpha, IL-1beta, iNOS) and macrophage accumulation in adipose tissue.Formal Name: 7-methoxy-1-methyl-9H-pyrido[3,4-b]indole. CAS Number: 442-51-3. Molecular Formula: C13H12N2O. Formula Weight: 212.3. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 1.5 mg/ml, DMSO: 2 mg/ml, Ethanol: 1.5 mg/ml, PBS (pH 7.2): 0.25 mg/ml. lambdamax: 242, 302 nm. SMILES: COc1ccc2c(c1)[nH]c1c(C)nccc21. InChi Code: InChI=1S/C13H12N2O/c1-8-13-11(5-6-14-8)10-4-3-9(16-2)7-12(10)15-13/h3-7,15H,1-2H3. InChi Key: BXNJHAXVSOCGBA-UHFFFAOYSA-N.