H-7 (hydrochloride)

H-7 is a non-selective inhibitor of protein kinases (PKs, IC50s = 20, 36, 7, and 420 µM for PKC, A, G, and M, respectively). It has been widely used to characterize the functional roles of PKC in a multitude of cellular processes.Formal Name: 5-[(2-methyl-1-piperazinyl)sulfonyl]-isoquinoline, dihydrochloride. CAS Number: 108930-17-2. Molecular Formula: C14H17N3O2S . 2HCl. Formula Weight: 364.3. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 2 mg/ml, DMSO: 10 mg/ml, Ethanol: 0.25 mg/ml, PBS (pH 7.2): 10 mg/ml. lambdamax: 217, 274, 323 nm. SMILES: O=S(C1=CC=CC2=CN=CC=C21)(N3C(C)CNCC3)=O.Cl.Cl. InChi Code: InChI=1S/C14H17N3O2S.2ClH/c1-11-9-16-7-8-17(11)20(18,19)14-4-2-3-12-10-15-6-5-13(12)14,,/h2-6,10-11,16H,7-9H2,1H3,2*1H. InChi Key: OARGPFMFRLLKPF-UHFFFAOYSA-N.