GW 441756

The high affinity nerve growth factor (NGF) receptor, also known as NGF tyrosine kinase receptor A (TrkA), is involved in the development and maturation of the nervous system. Aberrant expression is associated with certain forms of cancer and congenital insensitivity to pain with anhidrosis. GW 441756 is a potent inhibitor of TrkA (IC50 = 2 nM). It displays >100-fold selectivity over a panel of related kinases. GW 441756 has been used to clarify the role of TrkA in regulating gene expression in neuroblastoma cells and, more recently, in amyloid-beta protein precursor cleavage in neuroglioma cells.Formal Name: 1,3-dihydro-3-[(1-methyl-1H-indol-3-yl)methylene]-2H-pyrrolo[3,2-b]pyridin-2-one. CAS Number: 504433-23-2. Molecular Formula: C17H13N3O. Formula Weight: 275.3. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 1 mg/ml, DMSO: 5 mg/ml. lambdamax: 285, 375, 470, 500 nm. SMILES: CN1C=C(/C=C2C(NC3=C/2N=CC=C3)=O)C4=CC=CC=C41. InChi Code: InChI=1S/C17H13N3O/c1-20-10-11(12-5-2-3-7-15(12)20)9-13-16-14(19-17(13)21)6-4-8-18-16/h2-10H,1H3,(H,19,21)/b13-9+. InChi Key: NXNQLECPAXXYTR-UKTHLTGXSA-N.