Gue1654

Description: Gue1654 is a selective OXE-R inhibitor that attenuates coronary artery ligation-induced ischemic myocardial injury and cardiomyocyte oxygen/glucose deprivation-induced injury in mice through activation of BCAT1.Gue1654 inhibits OXE-R-inhibited protein kinase C-epsilon (PKC-epsilon)/nuclear factor kappaB (NF-kappaB) signaling and apoptosis in cardiomyocytes. Gue1654 can be used to study cardiovascular disease. Target: Others. Smiles: O=C(NC1=NC=2C=CC=3N=C(SC3C2S1)SC)C(C=4C=CC=CC4)C=5C=CC=CC5. References: Cossette C, Gravel S, Reddy CN, Gore V, Chourey S, Ye Q, Snyder NW, Mesaros CA, Blair IA, Lavoie JP, Reinero CR, Rokach J, Powell WS. Biosynthesis and actions of 5-oxoeicosatetraenoic acid (5-oxo-ETE) on feline granulocytes. Biochem Pharmacol. 2015 Aug 1,96(3):247-55. doi: 10.1016/j.bcp.2015.05.009. PubMed PMID: 26032638, PubMed Central PMCID: PMC4830392.