Guanosine-5'-O-(2-thiodiphosphate) (sodium salt)

Guanosine-5'-O-(2-thiodiphosphate) is a non-hydrolyzable derivative of GDP (Cay-31704) and an inhibitor of adenylyl cyclase (AC, Ki = 600 nM). It is also a partial activator of AC when GTP is absent in rat cerebral cortex membranes (EC50 = 400 nM). Guanosine-5'-O-(2-thiodiphosphate) (1 µM) prevents norepinephrine-induced nitric oxide (NO) release in cardiac ventricular myocytes. It reduces female opossum urine-induced firing frequency of olfactory mitral/tufted neuronal cells in male opossums when administered at a concentration of 100 µM.Formal Name: 5'-guanylic acid, monoanhydride with phosphorothioic acid, trisodium salt. Synonyms: GDP-beta-S. Molecular Formula: C10H12N5O10P2S . 3Na. Formula Weight: 525.2. Purity: >95%. Formulation: (Request formulation change), A solution in water. Solubility: Water: Soluble. SMILES: O[C@@H]1[C@H](O)[C@@H](COP([O-])(OP([O-])([S-])=O)=O)O[C@H]1N2C=NC3=C2NC(N)=NC3=O.[Na+].[Na+].[Na+]. InChi Code: InChI=1S/C10H15N5O10P2S.3Na/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(24-9)1-23-26(19,20)25-27(21,22)28,,,/h2-3,5-6,9,16-17H,1H2,(H,19,20)(H2,21,22,28)(H3,11,13,14,18),,,/q,3*+1/p-3/t3-,5-,6-,9-,,,/m1.../s1. InChi Key: WOKRDKNJTPRZNI-CYCLDIHTSA-K.