GSK3039294

GSK3039294 is a prodrug form of CPHPC (Cay-75500), an inhibitor of the protein-protein interaction between serum amyloid P (SAP) and amyloid fibrils. It is converted to CPHPC by hydrolysis via a monoester intermediate in rat, canine, and human liver microsomes.Formal Name: 1,1'-(1,6-dioxo-1,6-hexanediyl)bis-D-proline, 2,2'-bis[[[[(tetrahydro-2H-pyran-4-yl)oxy]carbonyl]oxy]methyl] ester. CAS Number: 1819986-22-5. Synonyms: GSK294. Molecular Formula: C30H44N2O14. Formula Weight: 656.7. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: DMSO: Sparingly soluble: 1-10 mg/ml. SMILES: O=C([C@@H]1N(C(CCCCC(N2[C@@H](C(OCOC(OC3CCOCC3)=O)=O)CCC2)=O)=O)CCC1)OCOC(OC4CCOCC4)=O. InChi Code: InChI=1S/C30H44N2O14/c33-25(31-13-3-5-23(31)27(35)41-19-43-29(37)45-21-9-15-39-16-10-21)7-1-2-8-26(34)32-14-4-6-24(32)28(36)42-20-44-30(38)46-22-11-17-40-18-12-22/h21-24H,1-20H2/t23-,24-/m1/s1. InChi Key: KSKLDMGKWDUQCT-DNQXCXABSA-N.