GSK2983559 free acid

Description: GSK2983559 free acid is an effective and selective inhibitor of receptor-interacting protein 2 (RIP2). GSK2983559 free acid shows excellent activity in blocking many proinflammatory cytokine responses in human inflammatory bowel disease explant samples an. Target: RIP kinase, Others. Smiles: N(C=1C2=C(C=C(OCCOP(=O)(O)O)C(S(C(C)(C)C)(=O)=O)=C2)N=CN1)C=3C=C4C(=CC3)SC=N4. References: Haile PA, et al. Discovery of a First-in-Class Receptor Interacting Protein 2 (RIP2) Kinase Specific Clinical Candidate, 2-((4-(Benzo[d]thiazol-5-ylamino)-6-(tert-butylsulfonyl)quinazolin-7-yl)oxy)ethyl Dihydrogen Phosphate, for the Treatment of Inflammatory Diseases. J Med Chem. 2019 Jul 25,62(14):6482-6494.