GSK2330672

GSK2330672 is an inhibitor of the sodium/bile acid and sulfated solute cotransporter (ASBT, IC50s = 42, 2.1, and 1.9 nM for human, mouse, and rat ASBT, respectively). In vivo, GSK2330672 (0.05 mg/kg) stimulates fecal bile acid secretion, reduces hemoglobin A1c (HbA1c) and plasma glucose levels, and increases total GLP-1 (Cay-24460) and plasma insulin in Zucker diabetic fatty (ZDF) rats.Formal Name: 3-[[[(3R,5R)-3-butyl-3-ethyl-2,3,4,5-tetrahydro-7-methoxy-1,1-dioxido-5-phenyl-1,4-benzothiazepin-8-yl]methyl]amino]-pentanedioic acid. CAS Number: 1345982-69-5. Molecular Formula: C28H38N2O7S. Formula Weight: 546.7. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 5 mg/ml, DMSO: 2 mg/ml, PBS (pH 7.2): 0.2 mg/ml. lambdamax: 206, 238 nm. SMILES: CC[C@@](N[C@@H]1C2=CC=CC=C2)(CCCC)CS(C3=C1C=C(OC)C(CNC(CC(O)=O)CC(O)=O)=C3)(=O)=O. InChi Code: InChI=1S/C28H38N2O7S/c1-4-6-12-28(5-2)18-38(35,36)24-13-20(17-29-21(14-25(31)32)15-26(33)34)23(37-3)16-22(24)27(30-28)19-10-8-7-9-11-19/h7-11,13,16,21,27,29-30H,4-6,12,14-15,17-18H2,1-3H3,(H,31,32)(H,33,34)/t27-,28-/m1/s1. InChi Key: CZGVOBIGEBDYTP-VSGBNLITSA-N.