This website uses cookies, which are necessary for the technical operation of the website and are always set. Other cookies, which increase the comfort when using this website, are used for direct advertising or to facilitate interaction with other websites and social networks, are only set with your consent.
Configuration
Technically required
These cookies are necessary for the basic functions of the shop.
"Allow all cookies" cookie
"Decline all cookies" cookie
CSRF token
Cookie preferences
Currency change
Customer-specific caching
FACT-Finder tracking
Individual prices
Selected shop
Session
Comfort functions
These cookies are used to make the shopping experience even more appealing, for example for the recognition of the visitor.
Note
Show the facebook fanpage in the right blod sidebar
Statistics & Tracking
Affiliate program
Conversion and usertracking via Google Tag Manager
GPR52 comp-43 is an antagonist of G protein-coupled receptor 52 (GPR52, IC50 = 0.63 µM). It reduces mutant huntingtin (mHTT) protein levels in STHdhQ7/Q111 cells, a heterozygous in vitro model of Huntington's disease, in a concentration-dependent manner. GPR52 comp-43 (3 µM) reduces apoptosis induced by growth factor deprivation in primary striatal neurons isolated from the heterozygous HdhQ7/Q140 mouse model of Huntington's disease. It decreases striatal levels of soluble and insoluble mHTT, as well as increases the latency to fall in the rotarod test, in the homozygous HdhQ140 mouse model of Huntington's disease, when administered at a dose of 5 mg/kg.Formal Name: (2E)-5-phenyl-1-(2-thienyl)-2-penten-1-one. CAS Number: 1239987-91-7. Synonyms: GPR52-IN-43. Molecular Formula: C15H14OS. Formula Weight: 242.3. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: Chloroform: 10 mg/ml. lambdamax: 270 nm. SMILES: O=C(C1=CC=CS1)/C=C/CCC2=CC=CC=C2. InChi Code: InChI=1S/C15H14OS/c16-14(15-11-6-12-17-15)10-5-4-9-13-7-2-1-3-8-13/h1-3,5-8,10-12H,4,9H2/b10-5+. InChi Key: XUIAIACHIPOOHR-BJMVGYQFSA-N.
This website uses cookies, which are necessary for the technical operation of the website and are always set. Other cookies, which increase the usability of this website, serve for direct advertising or simplify interaction with other websites and social networks, will only be used with your consent.
More information