Glutathione ethyl ester

Glutathione (GSH) ethyl ester is a cell-permeable derivative of GSH (Cay-10007461), a nucleophilic co-substrate to glutathione transferases. It increases mitochondrial GSH levels in C38 and IB3-1 epithelial lung cystic fibrosis cells when used at a concentration of 10 mM. GSH ethyl ester (10 mM) decreases reactive oxygen species (ROS) levels and TNF-alpha-induced IL-8 secretion in IB3-1 cells. GSH ethyl increases mitochondrial complex I, also known as NADH dehydrogenase, function and reduces depolarization of the mitochondrial membrane potential in IB3-1 when used at concentrations of 10 mM and 1mM, respectively. It decreases lipid oxidation and ferroptosis in cystine-deficient PANC-1, AsPC-1, BxPC-3, and S2-013 pancreatic cancer cells. GSH ethyl ester increases the viability of irradiated human lymphoid cells when used at a concentration of 5 mM.Formal Name: L-gamma-glutamyl-L-cysteinyl-glycine, 3-ethyl ester. CAS Number: 92614-59-0. Synonyms: GSH-EE, GSH ethyl ester, GSH monoethyl ester. Molecular Formula: C12H21N3O6S. Formula Weight: 335.4. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: PBS (pH 7.2): 10 mg/ml, Water: 20 mg/ml. SMILES: O=C([C@H](CS)NC(CC[C@H](N)C(O)=O)=O)NCC(OCC)=O. InChi Code: InChI=1S/C12H21N3O6S/c1-2-21-10(17)5-14-11(18)8(6-22)15-9(16)4-3-7(13)12(19)20/h7-8,22H,2-6,13H2,1H3,(H,14,18)(H,15,16)(H,19,20)/t7-,8-/m0/s1. InChi Key: JKRODHBGNBKZLE-YUMQZZPRSA-N.