Ginsenoside Ro

Ginsenoside Ro is a non-steroid glycoside that has been found in plants of the genus Panax and has anti-inflammatory, antithrombotic, and antiviral biological activities. It inhibits LPS-induced release of reactive oxygen species (ROS) and nitric oxide (NO) as well as inducible nitric oxide synthase (iNOS) and COX-2 protein expression in RAW 264.7 murine macrophages when used at a concentration of 200 µM. Ginsenoside Ro dose-dependently inhibits human platelet aggregation induced by thrombin (Cay-13188) in vitro and thrombin-induced disseminated intravascular coagulation (DIC) in rats when administered at a dose of 100 mg/kg. It increases the 20-day survival of Sendai virus-infected mice when administered at a dose of 1 mg per day for three days prior to infection. Topical administration of ginsenoside Ro (0.2 mg per animal) also stimulates hair regrowth after shaving in a mouse model of slowed hair regrowth.Formal Name: (3beta)-28-(beta-D-glucopyranosyloxy)-28-oxoolean-12-en-3-yl 2-O-beta-D-glucopyranosyl-beta-D-glucopyranosiduronic acid. CAS Number: 34367-04-9. Synonyms: Chikusetsusaponin V. Molecular Formula: C48H76O19. Formula Weight: 957.1. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: PBS (pH 7.2): 5 mg/ml. SMILES: CC1(C)CC[C@@](CC[C@]2(C)C3=CC[C@@]4([H])[C@@]2(C)CC[C@]5([H])[C@]4(C)CC[C@H](O[C@]6([H])O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]6O[C@@]7([H])[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O7)C5(C)C)(C(O[C@H]8[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O8)=O)[C@@]3([H])C1. InChi Code: InChI=1S/C48H76O19/c1-43(2)14-16-48(42(61)67-40-35(58)31(54)29(52)24(20-50)63-40)17-15-46(6)21(22(48)18-43)8-9-26-45(5)12-11-27(44(3,4)25(45)10-13-47(26,46)7)64-41-37(33(56)32(55)36(65-41)38(59)60)66-39-34(57)30(53)28(51)23(19-49)62-39/h8,22-37,39-41,49-58H,9-20H2,1-7H3,(H,59,60)/t22-,23+,24+,25-,26+,27-,28+,29+,30-,31-,32-,33-,34+,35+,36-,37+,39-,40-,41+,45-,46+,47+,48-/m0/s1. InChi Key: NFZYDZXHKFHPGA-QQHDHSITSA-N. Origin: Plant/Panax ginseng.