Ginsenoside Rg1

Ginsenoside Rg1 is a steroid glycoside that has been found in P. ginseng and has diverse biological activities. In vivo, ginsenoside Rg1 (10, 20, and 40 mg/kg) decreases blood glucose, IL-1beta, and IL-18 levels, increases insulin secretion, and inhibits hepatic and pancreatic activation of the NLRP3 inflammasome in a mouse model of diabetes induced by streptozotocin (STZ, Cay-13104). It facilitates fear extinction and decreases immobility time in the tail-suspension and forced swim tests in a mouse model of single-prolonged stress-induced post-traumatic stress disorder (PTSD). Ginsenoside Rg1 decreases hepatic alanine transaminase (ALT) and aspartate aminotransferase (AST) levels and attenuates hepatic steatosis in a mouse model of ethanol-induced hepatitis. It also decreases the abundance of Bacteroidetes in the large intestine, cortical neuron apoptosis, and latency to the platform in the Morris water maze in a tree shrew model of Alzheimer's disease induced by amyloid-beta (25-35) (Abeta (25-35)).Formal Name: 3beta,12beta-dihydroxydammar-24-ene-6alpha,20-diyl bis-beta-D-glucopyranoside. CAS Number: 22427-39-0. Synonyms: Ginsenoside A2, Panaxoside A, Panaxoside Rg1, Sanchinoside C1, Sanchinoside Rg1. Molecular Formula: C42H72O14. Formula Weight: 801.0. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 10 mg/ml, DMSO: 10 mg/ml, Ethanol:PBS (pH 7.2) (1:1): 0.5 mg/ml. SMILES: O[C@H]1[C@@]2([H])[C@](CC[C@]2([H])[C@@](CC/C=C(C)/C)(C)O[C@@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3O)(C)[C@]4(C)C[C@H](O[C@]5([H])O[C@H](CO)[C@@H](O)[C@H](O)[C@H]5O)[C@]6([H])[C@@](CC[C@H](O)C6(C)C)(C)[C@@]4([H])C1. InChi Code: InChI=1S/C42H72O14/c1-20(2)10-9-13-42(8,56-37-34(52)32(50)30(48)25(19-44)55-37)21-11-15-40(6)28(21)22(45)16-26-39(5)14-12-27(46)38(3,4)35(39)23(17-41(26,40)7)53-36-33(51)31(49)29(47)24(18-43)54-36/h10,21-37,43-52H,9,11-19H2,1-8H3/t21-,22+,23-,24+,25+. InChi Key: YURJSTAIMNSZAE-HHNZYBFYSA-N. Origin: Plant/Ginseng Radix et Rhizoma.