Ginsenoside Rc

Ginsenoside Rc is a saponin that has been found in P. ginseng and has diverse biological activities, including antioxidant, anti-inflammatory, and nootropic properties. It prevents UVB-induced increases in the levels of reactive oxygen species (ROS) in HaCaT keratinocytes by 34.3, 54.4, and 65.4% when used at concentrations of 5, 12, and 30 µM, respectively. Ginsenoside Rc (40 µg/ml) reduces increases in the expression of Tnf, Il1b, and Ifnb1 induced by LPS in RAW 264.7 cells. It reduces gastric ulcer and joint lesion indices in mouse models of HCl/ethanol-induced gastritis and collagen-induced arthritis, respectively, as well as reduces increased serum levels of aspartate aminotransferase (AST) induced by LPS/D-galactosamine in a mouse model of hepatitis, when administered at a dose of 20 mg/kg. Ginsenoside Rc increases GABA-induced inward current in Xenopus oocytes expressing recombinant human alpha1beta1?2S subunit-containing GABAA receptors with an EC50 value of 53.2 µM.Formal Name: (3beta,12beta)-20-[(6-O-alpha-L-arabinofuranosyl-beta-D-glucopyranosyl)oxy]-12-hydroxydammar-24-en-3-yl 2-O-beta-D-glucopyranosyl-beta-D-glucopyranoside. CAS Number: 11021-14-0. Synonyms: NSC 310104, Panaxoside Rc. Molecular Formula: C53H90O22. Formula Weight: 1079.3. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 15 mg/ml, DMSO: 10 mg/ml, Ethanol: 0.1 mg/ml, PBS (pH 7.2): 1 mg/ml. SMILES: O[C@H]1[C@@]2([H])[C@](CC[C@]2([H])[C@@](CC/C=C(C)/C)(C)O[C@@H]3O[C@H](CO[C@H]4[C@H](O)[C@@H](O)[C@H](CO)O4)[C@@H](O)[C@H](O)[C@H]3O)(C)[C@]5(C)CC[C@]6([H])[C@@](CC[C@H](O[C@H]7[C@H](O[C@H]8[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O8)[C@@H](O)[C@H](O)[C@@H](CO)O7)C6(C)C)(C)[C@@]5([H])C1. InChi Code: InChI=1S/C53H90O22/c1-23(2)10-9-14-53(8,75-47-43(67)39(63)37(61)29(72-47)22-68-45-41(65)36(60)28(21-56)69-45)24-11-16-52(7)33(24)25(57)18-31-50(5)15-13-32(49(3,4)30(50)12-17-51(31,52)6)73-48-44(40(64)35(59)27(20-55)71-48)74-46-42(66)38(62)34(58)26(19-54)70-46/h10,24-48,54-67H,9,11-22H2,1-8H3/t24-,25+,26+,27+,28-,29+,30-,31+,32-,33-,34+,35+,36-,37+,38-,39-,40-,41+,42+,43+,44+,45+,46-,47-,48-,50-,51+,52+,53-/m0/s1. InChi Key: JDCPEKQWFDWQLI-LUQKBWBOSA-N. Origin: Plant/Ginseng.