Ginkgetin

Ginkgetin is a biflavonoid that has been isolated from G. biloba and has diverse biological activities, including pro-apoptotic, antiproliferative, anti-inflammatory, anti-atherosclerosis, and neuroprotective properties. It inhibits the proliferation of OVCAR-3 ovarian and HeLa cervical cancer cells (EC50s = 3 and 5.2 µg/ml, respectively) and induces apoptosis and caspase-3 cleavage in OVCAR-3 cells when used at a concentration of 3 µg/ml. Topical ginkgetin (20 µg/ear) reduces ear edema and prostaglandin E2 (PGE2, Cay-14010) levels in a mouse model of chronic skin inflammation induced by phorbol 12-myristate 13-acetate (PMA, Cay-10008014). It decreases the thickness of the intima-media and lipid plaque deposition in the thoracic aorta in a rat model of high-fat diet-induced atherosclerosis when administered at a dose of 100 mg/kg. Ginkgetin (0.8 mg/kg per day) improves sensorimotor coordination and increases the time spent on a rotating bar in a mouse model of Parkinson's disease induced by MPTP.Formal Name: 5,7-dihydroxy-8-[5-(5-hydroxy-7-methoxy-4-oxo-4H-1-benzopyran-2-yl)-2-methoxyphenyl]-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one. CAS Number: 481-46-9. Molecular Formula: C32H22O10. Formula Weight: 566.5. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMSO: 3 mg/ml, DMSO:PBS (pH 7.2) (1:7): 0.12 mg/ml. lambdamax: 272, 331 nm. SMILES: O=C1C=C(C2=CC=C(O)C=C2)OC3=C1C(O)=CC(O)=C3C4=CC(C5=CC(C(C(O)=CC(OC)=C6)=C6O5)=O)=CC=C4OC. InChi Code: InChI=1S/C32H22O10/c1-39-18-10-20(34)30-23(37)13-27(41-28(30)11-18)16-5-8-25(40-2)19(9-16)29-21(35)12-22(36)31-24(38)14-26(42-32(29)31)15-3-6-17(33)7-4-15/h3-14,33-36H,1-2H3. InChi Key: AIFCFBUSLAEIBR-UHFFFAOYSA-N. Origin: Plant/Ginkgo biloba L..