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Gepotidacin is an inhibitor of bacterial topoisomerase II. It is active against 84 bacterial clinical isolates (MICs = 0.032-8 µg/ml) and vancomycin-resistant S. aureus (VRSA) and methicillin-resistant S. aureus (MRSA, MICs = 0. and 0. µg/ml, respectively). Gepotidacin reduces the number of lung colony-forming units (CFUs) in a mouse model of neutropenic S. aureus lung infection. Formulations containing gepotidacin have been used in the treatment of uncomplicated urinary tract infections. InChI: InChI=1S/C24H28N6O3/c31-22-4-3-20-24-29(22)15-19(30(24)23(32)13-27-20)14-28-7-5-17(6-8-28)25-11-18-10-16-2-1-9-33-21(16)12-26-18/h3-4,10,12-13,17,19,25H,1-2,5-9,11,14-15H2/t19-/m1/s1, InChIKey: PZFAZQUREQIODZ-LJQANCHMSA-N, SMILES: O=C1N(C2)C(N3[C@@H]2CN4CCC(CC4)NCC5=NC=C6OCCCC6=C5)=C(N=CC3=O)C=C1
This website uses cookies, which are necessary for the technical operation of the website and are always set. Other cookies, which increase the usability of this website, serve for direct advertising or simplify interaction with other websites and social networks, will only be used with your consent.
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