Gentiopicrin

Gentiopicrin is an iridoid glycoside that has been found in G. rigescens and has diverse biological activities. In vivo, gentiopicrin (130 mg/kg) attenuates acute cholestasis and liver damage and reverses bile acid dyshomeostasis induced by alpha-napthylisothiocyanate (ANIT) in mice. It increases the paw withdrawal threshold in the cold-plate test and latency to paw withdrawal in the plantar test in mice when administered at doses of 25, 50, and 100 mg/kg. Gentiopicrin (100 mg/kg) also decreases NMDA receptor-mediated excitatory postsynaptic currents (EPSCs) in the nucleus accumbens and reverses morphine-induced conditioned place preference in mice.Formal Name: (5R,6S)-5-ethenyl-6-(beta-D-glucopyranosyloxy)-5,6-dihydro-1H,3H-pyrano[3,4-c]pyran-1-one. CAS Number: 20831-76-9. Synonyms: Gentiopicroside, NSC 606402. Molecular Formula: C16H20O9. Formula Weight: 356.3. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 50 mg/ml, DMSO: 50 mg/ml, Ethanol: 2 mg/ml, PBS (pH 7.2): 10 mg/ml. lambdamax: 210, 245, 271 nm. SMILES: O=C1OCC=C2C1=CO[C@@H](O[C@]3([H])O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3O)[C@@H]2C=C. InChi Code: InChI=1S/C16H20O9/c1-2-7-8-3-4-22-14(21)9(8)6-23-15(7)25-16-13(20)12(19)11(18)10(5-17)24-16/h2-3,6-7,10-13,15-20H,1,4-5H2/t7-,10-,11-,12+,13-,15+,16+/m1/s1. InChi Key: DUAGQYUORDTXOR-GPQRQXLASA-N.