Gardenoside

Gardenoside is an iridoid glycoside that has been found in G. jasminoides and has anti-inflammatory and antinociceptive activities. It decreases free fatty acid-induced accumulation of lipid droplets and increases in TNF-alpha, IL-6, and IL-1beta levels in HepG2 cells when used at concentrations of 10 and 20 µM. Gardenoside reduces increases in the expression of purinergic P2X3 and P2X7 receptors, as well as reverses decreases in mechanical withdrawal thresholds in a rat model of chronic constriction injury-induced neuropathic pain.Formal Name: 1-(beta-D-glucopyranosyloxy)-1S,4aS,7S,7aS-tetrahydro-7-hydroxy-7-(hydroxymethyl)-cyclopenta[c]pyran-4-carboxylic acid, methyl ester. CAS Number: 24512-62-7. Synonyms: NSC 325664. Molecular Formula: C17H24O11. Formula Weight: 404.4. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: DMF: 30 mg/ml, DMSO: 10 mg/ml, Ethanol: 10 mg/ml, PBS (pH 7.2): 10 mg/ml. lambdamax: 237 nm. SMILES: COC(C1=CO[C@H]([C@@]2([H])[C@]1([H])C=C[C@@]2(O)CO)O[C@@H]3O[C@@H]([C@H]([C@@H]([C@H]3O)O)O)CO)=O. InChi Code: InChI=1S/C17H24O11/c1-25-14(23)8-5-26-15(10-7(8)2-3-17(10,24)6-19)28-16-13(22)12(21)11(20)9(4-18)27-16/h2-3,5,7,9-13,15-16,18-22,24H,4,6H2,1H3/t7-,9-,10-,11-,12+,13-,15+,16+,17-/m1/s1. InChi Key: XJMPAUZQVRGFRE-AYDWLWLASA-N. Origin: Plant/Gardenia jasminoides.