Ganoderic Acid A

Ganoderic acid A is a triterpene that has been found in Ganoderma and has diverse biological activities. It reduces cell viability, expression of superoxide dismutase 1 (SOD1), SOD2, and SOD3, and production of reactive oxygen species (ROS) in PC3 prostate cancer cells. It inhibits LPS-induced activation of NF-kappaB, release of TNF-alpha, IL-1beta, and IL-6, and mitochondrial activity in primary mouse cortical microglia. Ganoderic acid A (20 and 40 mg/kg) reduces lung myeloperoxidase (MPO) activity, neutrophil infiltration, and NF-kappaB signaling, as well as bronchoalveolar lavage fluid (BALF) levels of TNF-alpha, IL-1beta, and IL-6 in a mouse model of LPS-induced lung injury. It also reduces weight gain and hepatic lipid accumulation and improves insulin sensitivity in a mouse model of high-fat diet-induced obesity.Formal Name: (25R)-7beta,15alpha-dihydroxy-3,11,23-trioxo-lanost-8-en-26-oic acid. CAS Number: 81907-62-2. Molecular Formula: C30H44O7. Formula Weight: 516.7. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 5mg/mL, DMSO: 1 mg/mL, Ethanol: 3 mg/mL. lambdamax: 252 nm. SMILES: O=C1CC[C@@]2(C)[C@](C[C@H](O)C([C@@]([C@@H](O)C[C@]3([H])[C@H](C)CC(C[C@@H](C)C(O)=O)=O)(C)[C@]3(C)C4)=C2C4=O)([H])C1(C)C. InChi Code: InChI=1S/C30H44O7/c1-15(10-17(31)11-16(2)26(36)37)18-12-23(35)30(7)25-19(32)13-21-27(3,4)22(34)8-9-28(21,5)24(25)20(33)14-29(18,30)6/h15-16,18-19,21,23,32,35H,8-14H2,1-7H3,(H,36,37)/t15-,16-,18-,19+,21+,23+,28+,29-,30+/m1/s1. InChi Key: DYOKDAQBNHPJFD-JNTBEZBXSA-N. Origin: Fungus/Ganoderma lucidium karst..