Ganglioside GD1a mixture (sodium salt)

Description: Ganglioside GD1a is a sialic acid-containing glycosphingolipid found in brain, erythrocytes, bone marrow, testis, spleen, and liver. [1] It can be shed from the surface of tumor cells into the microenvironment where it influences tumor-host cell interactions to promote tumor cell proliferation, invasion, and metastasis. Ganglioside GD1a (20 µM) also increases endothelial cell proliferation. Furthermore, ganglioside GD1a has been shown to act as a functional coreceptor for toll-like receptor 2 (TLR2), enabling the recruitment of TLR2 to lipid rafts when bound by a bacterial toxin.[2] Ganglioside GD1a mixture contains ganglioside GD1a molecular species with C18:1 and C20:1 sphingoid backbones. Target: Others. Smiles: O[C@H]1[C@@H](O[C@@H]([C@H](O)[C@@H]1O[C@]2(O[C@H]([C@@H]([C@H](C2)O)NC(C)=O)[C@@]([H])([C@]([H])(O)CO)O)C([O-])=O)CO)O[C@H]3[C@H]([C@H](O[C@H]([C@@H]3NC(C)=O)O[C@@H]4[C@@H]([C@H]([C@@H](O[C@@H]4CO)O[C@H]5[C@@H]([C@H]([C@@H](O[C@@H]5CO)OC[C@@]([H])([. References: Mukherjee, P., Faber, A.C., Shelton, L.M., et al. Thematic review series: Sphingolipids. Ganglioside GM3 suppresses the proangiogenic effects of vascular endothelial growth factor and ganglioside GD1a. J. Lipid Res. 49(5), 929-938 (2008).