FzM1

Wnt signaling proteins are small secreted proteins that are active in embryonic development, tissue homeostasis, and tumorigenesis. Wnt proteins initiate cell signaling by binding Frizzled (Fz) receptors, a family of G protein-coupled receptors. FzM1 is an allosteric ligand of Fz4. At 10 µM, it inhibits nuclear translocation of beta-catenin in U87MG glioma cells treated with lithium chloride, a GSK3 inhibitor that enhances the Wnt canonical signaling pathway. FzM1 impairs the ability of U87MG cells to form neurospheres in culture and stimulates the differentiation of Caco-2 epithelial colorectal adenocarcinoma cells.Formal Name: N-[3-hydroxy-5-(2-thienyl)phenyl]-N'-2-naphthalenyl-urea. CAS Number: 1680196-54-6. Synonyms: Frizzled M1. Molecular Formula: C21H16N2O2S. Formula Weight: 360.4. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 12 mg/ml, DMF:PBS (pH 7.2)(1:3): 0.2 mg/ml, DMSO: 10 mg/ml. lambdamax: 211, 233, 261, 284 nm. SMILES: O=C(NC1=CC(O)=CC(C2=CC=CS2)=C1)NC3=CC4=CC=CC=C4C=C3. InChi Code: InChI=1S/C21H16N2O2S/c24-19-12-16(20-6-3-9-26-20)11-18(13-19)23-21(25)22-17-8-7-14-4-1-2-5-15(14)10-17/h1-13,24H,(H2,22,23,25). InChi Key: OBTSACXGWYGCPK-UHFFFAOYSA-N.