Fuscin

Fuscin is a quinonoid fungal metabolite originally isolated from O. fuscum that has diverse biological activities. It inhibits binding of the ADP/ATP translocase inhibitor atractyloside (Cay-14804) to rat liver mitochondria in an ADP-dependent manner when used at a concentration of 50 µM in a radioligand binding assay. Fuscin (20 µM) reduces the glutathione content of rat liver mitochondria to 28% of controls and inhibits NADH oxidation in sonicated pigeon heart mitochondria preparations in a concentration-dependent manner. It competes with macrophage inflammatory protein 1alpha (MIP-1alpha) for binding to CCR5 chemokine receptors in vitro with an IC50 value of 21 µM.Formal Name: 9,10-dihydro-5-hydroxy-4,8,8-trimethyl-2H,4H-benzo[1,2-b:4,3-c']dipyran-2,6(8H)-dione. CAS Number: 83-85-2. Molecular Formula: C15H16O5. Formula Weight: 276.3. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: DMSO: Soluble. SMILES: O=C1OC(C)C(C2=C1)=C(O)C(C3=C2CCC(C)(C)O3)=O. InChi Code: InChI=1S/C15H16O5/c1-7-11-9(6-10(16)19-7)8-4-5-15(2,3)20-14(8)13(18)12(11)17/h6-7,17H,4-5H2,1-3H3. InChi Key: OSJKAGRXDVEZQO-UHFFFAOYSA-N. Origin: Fungi.