FTase Inhibitor I

FTase inhibitor I is a potent inhibitor of farnesyltransferase (FTase, IC50 = 21 nM) that is greater than 30-fold selective for FTase over geranylgeranyl transferase (GGTase, IC50 = 790 nM). It prevents farnesylation of Ras and inhibits proliferation of cells transformed by Ras farnesylation. In a dog model of subarachnoid hemorrhage, it reduces GTP-Ras in spastic basilar arteries, decreases angiographic vasospasm, and improves clinical scores.Formal Name: N-[(2S)-2-[[(2R)-2-amino-3-mercaptopropyl]amino]-3-methylbutyl]-L-phenylalanyl-L-methionine. CAS Number: 149759-96-6. Synonyms: Farnesyltransferase Inhibitor I. Molecular Formula: C22H38N4O3S2. Formula Weight: 470.7. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: Water: Soluble. SMILES: O=C(N[C@H](C(O)=O)CCSC)[C@@H](NC[C@H](C(C)C)NC[C@@H](N)CS)CC1=CC=CC=C1. InChi Code: InChI=1S/C22H38N4O3S2/c1-15(2)20(24-12-17(23)14-30)13-25-19(11-16-7-5-4-6-8-16)21(27)26-18(22(28)29)9-10-31-3/h4-8,15,17-20,24-25,30H,9-14,23H2,1-3H3,(H,26,27)(H,28,29)/t17-,18+,19+,20-/m1/s1. InChi Key: QISLMXIYRQCLIR-FUMNGEBKSA-N.